Gradients of striatal function in antipsychotic-free first-episode psychosis and schizotypy

M Oldehinkel; J Tiego; K Sabaroedin; S Chopra; SM Francey; B O’Donoghue; V Cropley; B Nelson; J Graham; L Baldwin; HP Yuen; K Allott; M Alvarez-Jimenez; S Harrigan; C Pantelis; SJ Wood; P McGorry; MA Bellgrove; A Fornito

Journal article

Gradients of striatal function in antipsychotic-free first-episode psychosis and schizotypy

M Oldehinkel, J Tiego, K Sabaroedin, S Chopra, SM Francey, B O’Donoghue, V Cropley, B Nelson, J Graham, L Baldwin, HP Yuen, K Allott, M Alvarez-Jimenez, S Harrigan, C Pantelis, SJ Wood, P McGorry, MA Bellgrove, A Fornito

Translational Psychiatry | SPRINGERNATURE | Published : 2023

DOI: 10.1038/s41398-023-02417-2

Abstract

Both psychotic illness and subclinical psychosis-like experiences (PLEs) have been associated with cortico-striatal dysfunction. This work has largely relied on a discrete parcellation of the striatum into distinct functional areas, but recent evidence suggests that the striatum comprises multiple overlapping and smoothly varying gradients (i.e., modes) of functional organization. Here, we investigated two of these functional connectivity modes, previously associated with variations in the topographic patterning of cortico-striatal connectivity (first-order gradient), and dopaminergic innervation of the striatum (second-order gradient), and assessed continuities in striatal function from sub..

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University of Melbourne Researchers

Sidhant Chopra Author

Shona Francey Author

Brian O'Donoghue Author

Vanessa Cropley Author

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Grants

Awarded by Sylvia and Charles Viertel Charitable Foundation

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC Grant No. 1050504), Australian Research Council (Grant No. FT130100589), and the Sylvia and Charles Viertel Charitable Foundation. MO was supported by ZonMW Rubicon Grant No. 452172019. JT was supported by NHMRC project grants 1002458 and 1046054. VC was supported by a NARSAD Young Investigator Grant (21660), an NHMRC Investigator Grant (1177370) and an University of Melbourne Dame Kate Campbell Fellowship. BN was supported by an NHMRC Senior Research Fellowship (1137687) and a University of Melbourne Dame Kate Campbell Fellowship. KA was supported by an NHMRC Career Development Fellowship (1141207) and a University of Melbourne Dame Kate Campbell Fellowship. CP was supported by a National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship (1105825), an NHMRC Investigator Grant (1196508), and NHMRC Program Grant (ID: 1150083). MAB was supported by an NHMRC Senior Research Fellowship (Level B; Grant No. 1154378).